NEWS

How to cite miRWalk2.0? Dweep, H et al. miRWalk2.0: a comprehensive atlas of microRNA-target interactions, Nature Methods, 12(8): 697 (2015). (Nature Methods)

**other identifier-based datasets can be provided on request, please directly contact to Dr. Harsh Dweep at Harsh.Dweep@medma.uni-heidelberg.de


29.04.2015 - Information on validated miRNA-target interactions (Rdata and GSEA files) is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on KEGG pathways is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on WikiPathways is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on PantherDB pathways is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on GOBP, GOMF, GOCC is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on gene- and protein-classes is integrated.(Click Here)
29.04.2015 - Information on validated miRNA-target interactions on disease- and human phenotype-ontologies is integrated.(Click Here)

21.04.2015 - Information of the Validated Target module is corrected and updated.
17.04.2015 - Information on CLIP interactions (Rdata and GSEA files) is integrated. (Click Here)
07.04.2015 - Information on LncRNA-miRNA interactions (Rdata and GSEA files) is integrated. (Click Here)


02.02.2015 - Information on datasets for R package (Gene- and Entrez-based) is updated. (Click Here)
02.02.2015 - Information on datasets for R package (Refseq-based) is integrated. (Click Here)
31.01.2015 - Information on datasets for GSEA package (Refseq-based) is integrated. (Click Here)
31.01.2015 - Information on datasets for GSEA package (Gene- and Entrez-based) is updated. (Click Here)
23.11.2014 - Information on holistic view of gene-miRNA interaction datasets is integrated. (Click Here)
23.11.2014 - Information on datasets for R-statistical package is integrated. (Click Here)
23.11.2014 - Information on datasets for GSEA package is integrated. (Click Here)

Last updated on 7th April 2015

The Predicted Target module (PTM) is updated with the latest versions of 3rd party programs, whereas the Validated Target module (VTM) is last updated on 7th April 2015.

How to cite miRWalk2.0?


How to cite miRWalk2.0?

Dweep, H et al. miRWalk2.0: a comprehensive atlas of microRNA-target interactions, Nature Methods, 12(8): 697-697 (2015). (Nature Methods,   Pubmed)

Dweep, H et al. miRWalk - database: prediction of possible miRNA binding sites by "walking" the genes of 3 genomes, Journal of Biomedical Informatics, 44: 839-7 (2011). (JBI PubMed)

miRWalk citations :

Google Scholar   Scopus   PubMed


About miRWalk2.0


miRWalk2.0 is an improved version of the previous database (i.e. miRWalk). miRWalk2.0 is so far the only freely accessible, comprehensive archive, supplying the biggest available collection of predicted and experimentally verified miRNA-target interactions with various novel and unique features (missing in a previous version i.e. miRWalk) to greatly assist the miRNA research community.

miRWalk2.0 not only documents miRNA binding sites within the complete sequence of a gene, but also combines this information with a comparison of binding sites resulting from 12 existing miRNA-target prediction programs (DIANA-microTv4.0, DIANA-microT-CDS, miRanda-rel2010, mirBridge, miRDB4.0, miRmap, miRNAMap, doRiNA i.e.,PicTar2, PITA, RNA22v2, RNAhybrid2.1 and Targetscan6.2) to build novel comparative platforms of binding sites for the promoter (4 prediction datasets), cds (5 prediction datasets), 5’- (5 prediction datasets) and 3’-UTR (13 prediction datasets) regions. It also documents experimentally verified miRNA-target interaction information collected via an automated text-mining search and data from existing resources (miRTarBase, PhenomiR, miR2Disease and HMDD) offer such information.



miRWalk2.0 novelties are as follows:

The web-interface of miRWalk2.0 is broadly classified into the Predicted Target (PTM) and the Validated Target (VTM) modules.These two modules are further categorized into different search pages, allowing users to fetch miRNA associated information using different identifiers.

The Predicted Target module hosts miRNA-target interactions information within the complete sequence of all known genes of human, mouse and rat including all transcripts and mitochondrial genomes. It also provides novel comparative platforms of miRNA binding sites resulting from 13 data-sets for promoter, cds, 5'-, and 3'-UTR, mitochondrial genes and miRNA-miRNA interactions. miRBase release 20 is utilized to generated miRNA-target interaction information for this module.

The Validated Target module hosts experimentally verified miRNA interaction information associated with genes, pathways, organs, diseases, cell lines, OMIM disorders and literature on miRNAs. This module is last updated on 29th September 2014. In addition, it provides the information on proteins known to be involved in miRNA processing.



Word clouds of miRWalk2.0: